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首页 » 新冠疫情 » 不建议新冠感染者使用布洛芬是怎么回事?



  • 有理论推测布洛芬(常见品牌为美林 Motrin 和 Advil)可能会加重 Covid-19 新冠感染者病情,新冠感染者首选对乙酰氨基酚成分(Acetaminophen)的退烧药/止痛药(常见品牌为泰诺 Tylenol)。
  • 不宜服用对乙酰氨基酚的患者,请在医生指导下服用布洛芬
  • 布洛芬仍旧是安全性很高的退烧止痛药,非新冠感染者可继续服用布洛芬


2019 年 4 月 18 日,法国国家药品和保健产品安全局(French National Agency for Medicines and Health Products Safety)[来源],提醒医务人员和患者在治疗高位侵袭性链球菌感染发生风险者和水痘患者的发热时要谨慎,避免使用布洛芬。

2019 年 6 月 3 日,美国国家卫生研究院(National Institutes of Health)发表文章称 [来源],使用非甾体类抗炎药(布洛芬、阿司匹林类)引起肺炎病程恶化的机制仍然不确定,鼓励专家和科学协会反对使用非甾体类抗炎药治疗下呼吸道感染。

2020 年 3 月 11 日,《柳叶刀》杂志发表了一篇文章 [来源],提到布洛芬可以增加血管紧张素转化酶(ACE2)水平,而 ACE2 正好是 COVID-19 感染人体细胞的结合点,因此该文章推测布洛芬可能通过增加 ACE2 水平而加重 COVID-19 的感染风险和病情。

ACE2 can also be increased by thiazolidinediones and ibuprofen. These data suggest that ACE2 expression is increased in diabetes and treatment with ACE inhibitors and ARBs increases ACE2 expression. Consequently, the increased expression of ACE2 would facilitate infection with OVID-19. We therefore hypothesise that diabetes and hypertension treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19.

2020 年 3 月 14 日,法国卫生部长 Olivier Veran 发表 Twitter:

#COVID-19 | La prise d’anti-inflammatoires (ibuprofène, cortisone, …) pourrait être un facteur d’aggravation de l’infection. En cas de fièvre, prenez du paracétamol.
Si vous êtes déjà sous anti-inflammatoires ou en cas de doute, demandez conseil à votre médecin.


但法国卫生部长的意见并未获得很多支持,2020 年 3 月 18 日,欧洲药品管理局发表声明 [来源]目前尚无科学证据证明布洛芬与 COVID‑19 恶化之间存在联系。

There is currently no scientific evidence establishing a link between ibuprofen and worsening of COVID‑19. EMA is monitoring the situation closely and will review any new information that becomes available on this issue in the context of the pandemic.

When starting treatment for fever or pain in COVID-19, patients and healthcare professionals should consider all available treatment options including paracetamol and NSAIDs. Each medicine has its own benefits and risks which are reflected in its product information and which should be considered along with EU national treatment guidelines, most of which recommend paracetamol as a first treatment option for fever or pain.

In line with EU national treatment guidelines, patients and healthcare professionals can continue using NSAIDs (like ibuprofen) as per the approved product information. Current advice includes that these medicines are used at the lowest effective dose for the shortest possible period.

2020 年 3 月 18 日,世界卫生组织也发布 Twitter:根据目前可获得的信息,世卫组织不反对使用布洛芬



炎症反应适度,可以对抗病原体感染,所以大多数新冠感染者可自愈;炎症反应过度,则杀敌八百自损一千,引起部分新冠感染者病情恶化。至于布洛芬是否能影响人体对抗 COVID-19 的炎症反应过程,是否加剧 COVID-19 感染,目前没有科学证据。


Fan Zhao

Fan Zhao:爱烘培爱省钱的精明叻叻俏主妇。

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