健康医药

20种常见骨关节炎保健品的功效回顾

骨关节炎(Osteoarthritis)是最常见的关节炎类型。医疗手段治疗重点在于缓解关节疼痛、肿胀和功能减退等,常规药物包括非甾体抗炎药(NSAIDS),对乙酰氨基酚(一类止痛药)和皮质类固醇注射剂(抗炎激素)。非医疗方法就涉及很多方面,包括生活方式的改变,如运动和控制体重等。

美国常见的4类非处方止痛药
药房里常见的非处方止痛药有以下四种:对乙酰氨基酚、布洛芬、阿司匹林、萘普生钠。本文介绍一下常见品牌和各自的注意事项。 Fan Zhao 2019-06-27 3 评论 阅读全文

《英国医学杂志》的综述文章

《英国医学杂志》(BMJ)2017年10月刊发了一篇由澳大利亚悉尼大学6位研究人员撰写的综述文章 [来源],回顾了对20种骨关节炎保健品的69项研究,发现:

  • 有7种保健品对于短期缓解疼痛具有临床重要效果。
  • 有6种保健品对于缓解疼痛有统计显著效果、但临床重要性不明确。
  • 有两种保健品对于中期缓解疼痛有临床重要效果。
  • 没有保健品对于长期缓解疼痛有临床重要效果。

关于「临床重要效果」 (clinically important effects) 和「统计显著效果」 (statistically significant improvements) 的区别,可以阅读这篇文章:Statistical significance vs. clinical significance。简单点说:

  • 「临床重要效果」指受测药物/保健品可能对患者的日常生活产生真实、能明显感觉到的变化。
  • 「统计显著效果」指双盲对照试验中,产生的差异「比较明显」,P 值 < 0.05,不大可能是因为巧合。

再简单点说,对于药物和保健品的功效,「临床重要效果」更重要。

七种短期缓解关节疼痛的保健品

在英国医学杂志发表的综述文章中,以下7种保健品缓解关节疼痛的功效具有「临床重要效果」。

水解胶原蛋白

水解胶原蛋白(Collagen Hydrolysate)对于骨关节炎的功效,德国和美国研究者 2006 年在《当代医学研究与见解》(Current Medical Research and Opinion)上发表过一篇回顾文章 [来源],发现:

These findings suggest mechanisms that might help patients affected by joint disorders such as OA. Four open-label and three double-blind studies were identified and reviewed; although many of these studies did not provide key information – such as the statistical significance of the findings – they showed collagen hydrolysate to be safe and to provide improvement in some measures of pain and function in some men and women with OA or other arthritic conditions.

就是说,虽然还有待更多的关键信息,但目前的很多研究表明,水解胶原蛋白安全,并且在一些患有骨关节炎或其他关节炎的男性和女性病人中,在一定程度上缓解了疼痛、改善了关节能力。

Great Lakes Pure, Unflavored Collagen, 16oz Can
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Great Lakes Pure, Unflavored Collagen, 16oz Can
  • COLLAGEN HYDROLYSATE - The unique combination of amino acids in concentrated levels can promote healing and conditioning over other proteins. If used properly with a balanced and sensible diet, gelatin can be also be quite healthy as leading nutritional researchers have found that it's an excellent source of protein and the calcium.
  • SKIN AND HAIR - As we age collagen production declines and you may notice it with looser skin, more wrinkles, and less elasticity. When you increase collagen levels you notice the skin looking firmer, increased smoothness, and keeping skin cells renewing and repairing normally.
  • JOINTS - When we lose collagen, the tendons and ligaments start moving with less ease, leading to stiffness, and swollen joints. When you increase collagen, it is like greasing your joints to help you move around easily, reduce joint pain, and reduce the risk of joint deterioration.

百香果果皮精华

伊朗、美国和新西兰的研究者 2010 年发表在《营养研究》(Nutrition Research)论文显示 [来源],在针对33名膝关节炎患者的双盲试验中,每日服用150毫克百香果果皮精华(passion fruit peel extract)的患者,60天后疼痛下降18.6%、关节僵硬缓解18%、关节功能改善19.6%。研究人员认为这可能是由于百香果果皮精华的抗氧化和消炎特性。遗憾的是我们并未找到哪里有卖,包括 Amazon ……

姜黄精华

印度研究者2016年发表在 Inflammopharmacology 上的论文显示 [来源],在针对160名膝关节炎患者的双盲试验中,服用姜黄精华(Curcuma Longa Extract) 的患者在60天和120天后,相比对照试验组有明显的改善。研究者的结论是:姜黄精华能抑制发炎、并减轻氧化应激(oxidative stress)。

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Turmeric Curcumin with BioPerine - #1 Best Joint Supplement for Pain Relief & Joint Support, Vegan Turmeric Capsules with 100% Pure Turmeric Root (Curcuma) & Black Pepper, 60 Turmeric Pills
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Turmeric Curcumin with BioPerine - #1 Best Joint Supplement for Pain Relief & Joint Support, Vegan Turmeric Capsules with 100% Pure Turmeric Root (Curcuma) & Black Pepper, 60 Turmeric Pills
  • TURMERIC CURCUMIN SUPPLEMENT 100% SATISFACTION GUARANTEE: Feel healthier and stronger with NutriRise Turmeric Capsules - or your money back!*
  • ALL NATURAL, NON-GMO, PURE TURMERIC PILLS: NutriRise Pure Turmeric Curcumin Capsules contain 1300 mg of natural turmeric powder (curcumin powder) derived from 100% pure turmeric root and are FREE of gluten, dairy, binders, fillers, preservatives and allergens.*
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齿叶乳香精华

印度研究者2004年发表在 Phytomedicine 的论文显示 [来源],在针对30名膝关节炎患者的双盲试验中,服用齿叶乳香精华(Boswellia Serrata Extract) 8周后,患者疼痛缓解、 膝部屈伸(knee flexion)得以改善、可行走距离增加、膝关节肿胀的频率减少。除轻微的肠胃不适外,试验对象耐受良好、没有明显的副作用。

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Premium Boswellia Serrata Extract | 500mg 120 Veggie Capsules | Standardized 65% Boswellic Acids with AKBA | Natural Ayurvedic Supplement (Indian Frankincense) for Inflammation and Joint Pain Relief*
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Premium Boswellia Serrata Extract | 500mg 120 Veggie Capsules | Standardized 65% Boswellic Acids with AKBA | Natural Ayurvedic Supplement (Indian Frankincense) for Inflammation and Joint Pain Relief*
  • HIGHEST QUALITY 100% Pure Boswellia Serrata Extract. Extracted from the premium third harvest of the gum resin, which is considered to be the highest grade and have the most effective natural health results on inflammation and joint pain.* Ready to try to reduce the pain from inflammation, menstrual cramping, or migraines? Give it a try, with a 100% satisfaction guarantee!
  • EFFECTIVE INFLAMMATION SUPPLEMENT In Ayurvedic medicine Indian frankincense has been used for hundreds of years. Studies have shown positive effects of boswellia in some inflammatory issues.* Supports a stronger metabolism and can act as a natural mood booster.*
  • GREAT PRICE Long lasting high dosage 500mg per capsule, 120 vegetable capsules. Standardized to a potent minimum of 65% boswellic acids. 6-8:1 extract ratio!

姜黄素

姜黄素(Curcumin)是姜黄的有效成分,其功效参见上文「姜黄精华」。美国关节炎基金会(Arthritis Foundation)官网列举了几项相关的研究 [来源]

  • 多项研究表明姜黄素有抗炎功效、并修改人体的免疫功能反应。
  • 2006年一项研究表明,相比于缓解炎症,姜黄素对于预防关节炎更有效。
  • 2010年一项研究发现,100名膝关节炎患者服用姜黄素保健品 Meriva 后疼痛和关节功能得到了长期改善。
  • 2012年一项小规模的预备研究发现,类风湿关节炎患者使用姜黄素产品 BCM-95,其减缓关节疼痛及肿胀的效果好于非甾体抗炎药双氯芬酸(Diclofenac)。
Thorne Research - Meriva SF (Soy Free) - Sustained-Released Curcumin Phytosome Supplement - 120 Capsules
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Thorne Research - Meriva SF (Soy Free) - Sustained-Released Curcumin Phytosome Supplement - 120 Capsules
  • OPTIMAL ABSORPTION: Curcumin bound to phospholipids for optimal absorption in a sustained-release matrix
  • INFLAMMATORY RESPONSE: Helps maintain a healthy inflammatory response in joints, muscles, GI tract, liver, eyes, and nerves*
  • ACHES: Relief from occasional aches, joint stiffness, or muscle soreness*
Terry Naturally CuraMed 750 mg - 60 Softgels - Superior Absorption BCM-95 Curcumin Supplement, Promotes Healthy Inflammation Response - Non-GMO, Gluten-Free, Halal - 60 Servings
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Terry Naturally CuraMed 750 mg - 60 Softgels - Superior Absorption BCM-95 Curcumin Supplement, Promotes Healthy Inflammation Response - Non-GMO, Gluten-Free, Halal - 60 Servings
  • Up to 700% Better Absorption; CuraMed is made with the most clinically studied, enhanced absorption curcumin in the world (BCM-95/Curcugreen); It is up to 500x more powerful than turmeric!
  • Over 50 Published Studies; This patented, enhanced absorption curcumin with turmeric essential oil containing ar-turmerone has been the subject of over 50 groundbreaking, published studies
  • Safe and Effective; The combination of curcumin and turmeric essential oil in CuraMed supports liver, brain, heart, and immune health; CuraMed has a high antioxidant ORAC value and supports healthy inflammation response throughout the body

碧萝芷

据美国关节炎基金会官网的介绍 [来源],碧萝芷(Pycnogenol)含有原花青素( Procyandin),这是一种强效抗氧化剂,并且似乎能抑制人体内引起发炎的酶,包括 COX 1 和 COX 2。2007年亚利桑那大学的一项小型研究发现碧萝芷缓解关节疼痛达到43%、缓解关节僵硬达到25%。2008年的两项研究表明,关节疼痛、僵硬、功能均有明显改善,效果持续到停用之后。不过,2012年的一项回顾认为这些研究设计不合理、缺乏说服力。

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Pycnogenol 100mg from French Maritime Pine Bark Extract - Great for Healthy Circulation and Female Hormone Support, Plus Joint Support, Immune Function and Antioxidant Benefits; 60 Veggie Capsules.
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Pycnogenol 100mg from French Maritime Pine Bark Extract - Great for Healthy Circulation and Female Hormone Support, Plus Joint Support, Immune Function and Antioxidant Benefits; 60 Veggie Capsules.
  • POWERFUL CIRCULATION SUPPLEMENT TO SUPPORT HEALTHY BLOOD FLOW & JOINT HEALTH* - Shown in numerous clinical studies to support the health of your heart, circulation and cardiovascular system, Pycnogenol 100mg is an important circulation supplement made from French pine bark extract, ideal for anyone looking to promote healthy blood flow and nutrient delivery to your brain, joints, muscles, and other vital organs.*
  • REDUCE MENSTRUAL DISCOMFORT BY UP TO 34%* & DECREASE SEVERITY OF PERIMENOPAUSAL SYMPTOMS BY UP TO 46%* - Women across the country have turned to Pycnogenol 100mg for it's remarkable ability to support menstrual discomfort and reduce the severity of perimenopausal symptoms.* In one landmark study, women experienced a 34% reduction in abdominal menstrual discomfort during their first cycle with Pycnogenol.*
  • HELPS REDUCE THE EFFECTS & DURATION OF COLD SYMPTOMS* - So much more than a circulation supplement, Pycnogenol has been shown in a European clinical trial to support the immune system, reducing the effects and duration of common cold symptoms by 26%.* This same study also showed that Pycnogenol was effective at reducing the annoying stuffy and runny nose we often experience with a cold.*

左旋肉碱

关于左旋肉碱(L-carnitine)和关节炎的研究似乎较少,我大致查了下只看到意大利研究者于2014年发表在 Life Sciences 上的论文 [来源],是小鼠的动物实验,表明左旋肉碱可能有减缓关节僵化的功效,有用于膝关节炎治疗的潜力。

L-Carnitine 1000mg Servings 120 Tablets - Carnitine Amino Acid - Arazo Nutrition USA
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L-Carnitine 1000mg Servings 120 Tablets - Carnitine Amino Acid - Arazo Nutrition USA
  • SUPPORTS ATHLETIC PERFORMANCE AND STAMINA - Faster muscle recovery, delay exhaustion.
  • BURNS FAT TO HELP LOSE WEIGHT - Promotes muscle growth and fat loss during workouts
  • HEALTHY HEART - Transports Fatty Acids to support your Cardiovascular Energy Levels

左旋肉碱还是一种常见的减肥保健品,我们在下面这篇文章里有介绍。

2019 美国减肥药和保健品介绍
发胖如山倒、减肥如抽丝,很多人因此病急乱投医,包括 OTC 药品和保健品,有些号称 FDA approved,有些号称 Clinically tested,到底有没有效? Fan Zhao 2019-07-29 0 评论 阅读全文

另外六种可能缓解关节疼痛的保健品

在英国医学杂志发表的综述文章中,以下7种保健品缓解关节疼痛的功效具有「统计显著性」,其中葡萄糖胺和软骨素合并在一起介绍。另外,非变形第二型胶原蛋白(Undenatured Type II Collagen)除了短期缓解疼痛的「统计显著性」效果外,对于中期缓解疼痛有「临床重要效果」。

非变形第二型胶原蛋白

NOW Supplements, UC-II Type II Collagen with Undenatured Type II Collagen, 120 Veg Capsules
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NOW Supplements, UC-II Type II Collagen with Undenatured Type II Collagen, 120 Veg Capsules
  • WITH UNDENATURED TYPE II COLLAGEN: Derived from chicken sternum cartilage, UC-II is a patented form of collagen with undenatured (native) type II collagen that works with the immune system to support healthy joints.* Human clinical studies have found that just one 40 mg capsule of UC-II per day can help to promote joint comfort, as well as healthy joint function and flexibility.*
  • PROMOTES HEALTHY JOINT COMFORT AND FUNCTION*: Cartilage is one of the primary connective tissues of the body, providing flexibility and support to joints. Undenatured type II collagen is the principal structural protein in cartilage that is responsible for its tensile strength and toughness.*
  • CERTIFICATIONS/CLASSIFICATIONS: Kosher, Non-GMO, Soy Free, Dairy Free, Egg Free, Made without Gluten, Nut Free, Sugar Free

鳄梨/大豆不皂化物

鳄梨/大豆不皂化物( Avocado-soybean unsaponifiables;ASU)是由鳄梨油和大豆提取物制成的补充剂。NIH 的综述和 BMJ 的研究都认为,ASU 可能对骨关节炎症状有益。Mayo Clinic 对骨关节炎的综述表示 [来源]:"It [ASU] acts as an anti-inflammatory, and some studies have shown it can slow or even prevent joint damage." 它有抗炎的作用,有些研究发现它可以减缓甚至预防关节损伤。

Cosamin ASU Advanced Formula, 90 Capsules
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Cosamin ASU Advanced Formula, 90 Capsules
  • One of our newest discoveries and our maximum strength formula for people with joint discomfort
  • Asu, avocado soybean unsaponifiable is obtained from avocados and soybeans and has been shown to inhibit components that result in cartilage breakdown
  • Ingredients shown in laboratory cell culture studies to work better than just the combination of glucosamine + chondroitin sulfate

磺酰甲烷

甲磺酰甲烷( methylsulfonylmethane;MSM)已用于治疗关节炎相关病症。然而,目前关于 MSM 对骨关节炎疗效的证据仅限于临床试验报告和少数研究的元分析。 英国运动医学杂志的研究表明:MSM 在短期内改善骨关节功能有较大的临床影响。

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NOW MSM 1000mg  240 Veg Capsules
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NOW MSM 1000mg 240 Veg Capsules
  • JOINT SULFUR FOR CONNECTIVE TISSUE*: MSM, in its role in the body's sulfur cycle, helps to create the chemical links needed to form and maintain numerous different types of structural tissues of the human body, including connective tissues, such as articular cartilage and skin.*
  • VEGAN CAPSULES/SUPPORTS HEALTHY CARTILAGE*: Sulfur compounds are found in all body cells and are indispensable for life.*
  • CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Dairy Free, Egg Free, Made without Gluten, Corn Free, Soy Free, Kosher, Vegan/Vegetarian

安必丁

安必丁(Diacerein)现在是药物,不是保健品。

葡萄糖胺和软骨素

Doctor's Best Glucosamine Chondroitin Msm with OptiMSM, Supports Healthy Joint Structure, Function & Comfort, Non-GMO, Gluten Free, Soy Free, 240 Caps
1,766 个好评
Doctor's Best Glucosamine Chondroitin Msm with OptiMSM, Supports Healthy Joint Structure, Function & Comfort, Non-GMO, Gluten Free, Soy Free, 240 Caps
  • Glucosamine/chondroitin/MSM with optimism: the ultimate combination for healthy joints! Glucosamine supplements are used to help prevent the breakdown of joint tissues and any associated symptoms including pain, lack of flexion, joint stiffness and weakness. Chondroitin helps keep joints healthy by absorbing fluid (particularly water) in the bones. Msm provides a source of dietary sulfur and half of the body's sulfur is found in the skin, muscles, and bones. Sulfur is a critical building blocker, strengthens joint tissues and helps with elasticity.*
  • Improve joint flexibility: a potent combination of three proven, purified ingredients that help build and serves as a shock absorber for your joints. Healthy joints may get worn away by sports injuries, overuse, or wear-and-tear that can cause joint discomfort.*
  • Benefits of glucosamine/chondroitin/MSM with optimism: helps supports joint mobility, joint structure, and can increase joint flexibility while protecting joint tissue. Also supports overall health for hair, skin, and nails.*

很受欢迎的 Move Free 维骨力,核心成分就是葡萄糖胺(Glucosamine) 、软骨素(Chondroitin)和 MSM。

Move Free 维骨力5种瓶装的功效和区别
Move Free 维骨力是很受欢迎的骨骼保健品,有红盒、绿盒、蓝盒、紫盒、白盒5种包装。 Derek Yang 2019-07-28 1 评论 阅读全文

S-腺苷甲硫氨酸

本项根据美国国家研究院的综述文章补充 [来源]。S-腺苷甲硫氨酸(SAMe)是人体自然产生的一种分子,不过保健品里的 SAMe 都是人工合成。NIH 综述表示:目前没有足够的证据支持将 SAMe 用于膝关节或髋关节骨关节炎。Mayo Clinic 对 SAMe 的综述说 [来源],有很多研究发现 SAMe 和非甾体抗炎药的功效类似,可以缓解疼痛、增强关节功能,并且副作用较少;但也有较少的研究中并未证实此种功效。换言之,其功效仍然有争议。

Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets
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Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets
  • Doctor's Best SAMe Double Strength is proven to enhance mood and promote cognitive health
  • SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine
  • SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification

SAMe 通常来说安全,常见副作用包括肠胃不适、口干、头痛、出汗、头晕等。

中期缓解关节疼痛的两种保健品

除了短期功效外,英国医学杂志发布的综述文章还讨论了中期功效,只有两种保健品具有「临床重要意义」,一是上面已经介绍过的非变形第二型胶原蛋白,还有一个是绿唇贻贝精华(green-lipped mussel extract)。

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Swanson Green Lipped Mussel (Freeze Dried) New Zealand Joint Health Supplement 500 mg 60 Capsules
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Swanson Green Lipped Mussel (Freeze Dried) New Zealand Joint Health Supplement 500 mg 60 Capsules
  • POTENT JOINT HEALTH SUPPORT - Our green lipped mussel capsules are an excellent source of a type of an omega-3 fatty acid known as Eicosatetraenoic acid (ETA), which nourishes and comforts joints. Green lipped mussels also contain chondroitin sulfate, a well-known supporter of joint health.
  • EFFECTIVE GI DEFENSE - Green Lipped Mussels have been found to promote the protective lining of the digestive tract while simultaneously helping to stimulate the growth of friendly bacteria our gut needs to digest food and support the immune system.
  • BOOSTS CARDIOVASCULAR WELLNESS - Taking a green lipped mussel supplement may enhance cardiovascular wellness and it may even aid in the health of the arterial walls, according to recent studies.

绿唇贻贝是一种盛产于新西兰的贝类。美国关节炎基金会介绍 [来源],这些贝类富含 Omega-3,可能和鱼油含有同样的抗炎功效。一项2006年的回顾发现,在5项临床研究中,有两项发现绿唇贻贝精华对骨关节炎和类风湿性关节炎有益。2008年的一项骨关节炎研究回顾发现,在传统治疗手段中加入绿唇贻贝精华有益处。另外,非甾体抗炎药可能刺激肠胃,而绿唇贻贝精华反而可能有助于溃疡愈合。

美国药剂师推荐的骨骼和关节保健品
人体骨密度通常在25~35岁达到峰值,之后逐渐下降。除了均衡饮食、多摄入高钙食物外,一些保健品也能帮助减缓关节软骨退化、维持关节灵活性以及强化软骨。 Jia Liu 2019-07-29 2 评论 阅读全文
美国药剂师推荐的关节炎和关节疼痛外用药
外用镇痛药可能缓解关节炎和关节疼痛,本文介绍一下美国药剂师推荐的品牌。 Derek Yang 2019-07-29 2 评论 阅读全文
美国常见保健品的功效与注意事项
持续更新的保健品知识,参考国立卫生研究院、FDA、Mayo Clinic 等权威信息。 Derek Yang 2019-08-17 186 评论 阅读全文
【收藏】美国保健品推荐和攻略
美国保健品的种类和品牌都很多,相比中国市场来说更安全可靠,不管是自己用,还是带回国给家人朋友送礼都很好。 Derek Yang 2019-07-31 14 评论 阅读全文

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在线生成美国法律文书与合同的网站
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美国最好的4个购物和海淘返利网站
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2019 翻墙回中国好用的 VPN 推荐
2019 翻墙回中国好用的 VPN 推荐
2019 翻墙回中国好用的 VPN 推荐
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8月份银行开户奖励汇总
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Jia Liu, 80后,不会讲东北话的东北人,家有爱搞怪小儿一名。目标 - 希望自己很靠谱。

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